The impact of fullerenols on streptozotocin-induced diabetic rats: Fullerenes, Nanotubes and Carbon Nanostructures: Vol 0, No 0

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Summary

We help the overall understanding that deleterious results induced by hyperglycemia in rats could be alleviated by the use of antioxidant remedy. Additionally, we now have been supported and inspired by many explorations on the utilization of fullerenols for treating diabetic issues. Our current research goals to look at the potentials of fullerenols in opposition to diabetes in streptozotocin-induced diabetic rats. Animals have been intraperitoneally administered with fullerenols for 15 days after which sacrificed. Following parameters have been assessed: blood glucose, insulin focus, ranges of redox-related parameters, liver and kidney operate biomarkers, glycogen contents, carbohydrate metabolic enzyme actions and histopathological evaluation. As anticipated, fullerenols exhibited the well-known anti-oxidative property by way of lowering MDA, rising SOD, GSH-Px and CAT ranges. Fullerenol remedy additionally confirmed a slight enchancment in liver and kidney purposeful biomarkers, inferring a marginal hepatorenal safety. Nevertheless, there have been insignificant modifications in ranges of blood glucose, insulin, the pathological state of the necrotic islets. Herein, our outcomes revealed that fullerenols failed to enhance the operate of pancreas and reverse the hyperglycemia in streptozotocin-induced diabetic rats regardless of a potent antioxidant position. Our research urged that neither diabetes nor its issues may gain advantage from fullerenol administration.

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